Pharmacokinetics of invermectin in sea bream, Sparus aurata using a direct competitive ELISA

TitlePharmacokinetics of invermectin in sea bream, Sparus aurata using a direct competitive ELISA
Publication TypeJournal Article
Year of Publication2002
AuthorsKatharios, P, Iliopoulou-Georgudaki J, Antimisiaris S, Kantzaris V, Pavlidis M
JournalFish Physiology and Biochemistry
Volume26
Issue2
Pages189 - 195
KeywordsELISA, Ivermectin, Pharmacokinetics, Sparus aurata
Abstract

The pharmacokinetics of ivermectin in the serum of cultured sea bream, Sparus aurata, after a single intraperitoneal injection of 100 μg kg-1 body weight was studied by the use of direct competitive ELISA. Pharmacokinetic analysis of the serum concentrations versus time points obtained was performed using non-comparmental analysis and a compartmental pharmacokinetic model approach. In the latter case a two-compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 308.4 ng ml-1 at 2 h post treatment. The AUC of ivermectin was 10700 ng h ml-1 and the elimination half-life 15.37 h, indicating a rapid uptake, high bioavailability and fast elimination of the drug by sea bream.

URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0141496418&partnerID=40&md5=59a83d47b786ca9c2886af303b986026

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