Pharmacokinetics of cephalexin in sea bream, Sparus aurata (L.), after a single intraperitoneal injection

TitlePharmacokinetics of cephalexin in sea bream, Sparus aurata (L.), after a single intraperitoneal injection
Publication TypeJournal Article
Year of Publication2004
AuthorsKatharios, P, Iliopoulou-Georgudaki J, Antimisiaris S, Verri T, Toma P, Acierno R, Maffia M
JournalJournal of Applied Ichthyology
Volume20
Issue5
Pages422 - 426
Abstract

The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg-1). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non-compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two-compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml-1 kg-1 1 h post-treatment. The area under the curve (AUC) cephalexin was 17.394 mg·h kg-1 and the elimination half-life of 1.83 h. © 2004 Blackwell Verlag, Berlin.

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