Leaching, palatability and digestibility of oxytetracycline and oxolinic acid included in diets fed to seabass Dicentrarchus labrax L.

TitleLeaching, palatability and digestibility of oxytetracycline and oxolinic acid included in diets fed to seabass Dicentrarchus labrax L.
Publication TypeJournal Article
Year of Publication1999
AuthorsRigos, G, Alexis M, Nengas I
JournalAquaculture Research
Volume30
Issue11-12
Pages841 - 847
Abstract

The leaching of oxolinic acid (OA) and oxytetracycline (OTC) from medicated feeds, as well as the palatability and digestibility of these drugs were investigated in seabass Dicentrarchus labrax L. (350g) at 16°C and 24°C water temperature. Oil- coated OA and OTC on feeds were greatly affected by leaching at 16 °C (losses of 55.5% and 42.5% for OA and OTC respectively) and 24 °C (32% for OA and 47% for OTC). However, a significant reduction in drug loss resulting from leaching was evident when the antibiotics were mixed with the diet at 16°C (5% for OA and 6.5% for OTC) and 24°C (10% and 20% for OA and OTC respectively). Increased water temperature induced a significant effect on the leaching of both drugs when mixed with the feed, but did not affect the loss of oil-coated drugs. There was a significant reduction in feed consumption of fish fed a diet with oil-coated OTC (90% and 92% at 16°C and 24°C respectively), whereas intake of feed containing oil-coated OA was only slightly affected (10% at 16 °C, 12% at 24 °C). The depressed palatability of feeds containing oil-coated OTC was overcome by mixing the drug with the diet. Both antibiotics were well digested by seabass (94% and 85% for OA and OTC respectively) at 24°C; however, more than one-third of each drug was recovered in the faeces at 16 °C (64% and 59% for OA and OTC respectively). The significance of these findings for the interaction between fish therapy and marine environment is stressed.

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