The kinetic profile of oxolinic acid in sharpsnout sea bream, Diplodus puntazzo (Cetti 1777)

TitleThe kinetic profile of oxolinic acid in sharpsnout sea bream, Diplodus puntazzo (Cetti 1777)
Publication TypeJournal Article
Year of Publication2004
AuthorsRigos, G, Tyrpenou AE, Nengas I, Alexis M, Troisi GM
JournalAquaculture Research
Volume35
Issue14
Pages1299 - 1304
KeywordsBioavailability, Oxolinic acid, Pharmacokinetics, Sharpsnout sea bream Diplodus puntazzo
Abstract

The pharmacokinetics of oxolinic acid (OA) were investigated after a single intra-vascular injection (20 mg kg-1 fish) in sharpsnout sea bream (90 g), a promising new euryhaline species for Mediterranean fish farming. The distribution half-life (t1/2α) and the elimination half-life (t1/2β) of OA were calculated to be 0.4 and 10 h respectively. The apparent volume of distribution at steady-state (Vd(ss)) and total clearance rate (CLT) of the drug were found to be 2.1 L kg and 0.2 L kg-1 h-1 respectively. The bioavailability (F%) of OA following oral administration (40 mg kg-1 fish) fish) was estimated to be 15%. The results indicate a rapid distribution and elimination of the drug, moderate tissue penetration, but low absorption in sharpsnout sea bream. The kinetic profile of OA found in this species is comparable with that observed in another well-known sparid, gilthead sea bream.

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