Genetic mapping of the ornithine decarboxylase (odc) gene complex in rainbow trout (Oncorhynchus mykiss)

TitleGenetic mapping of the ornithine decarboxylase (odc) gene complex in rainbow trout (Oncorhynchus mykiss)
Publication TypeJournal Article
Year of Publication2009
AuthorsTuziak, SM, Moghadam HK, Danzmann RG
JournalCytogenetic and Genome Research
Volume125
Issue4
Pages279 - 285
Keywords4R duplicated genes, Cell cycling, growth, Polyamine regulation, QTL associations, Salmonids
Abstract

Ornithine decarboxylase (odc) and its associated gene complex, including antizymes of ODC and inhibitors of the antizymes, play a key role in regulating the overall polyamine levels (i.e., putrescine) in cells. Polyamine production levels are intricately coupled to mitotic and cellular turnover rates. Hence, these genes may be important candidates of growth regulation in vertebrates, if their chromosomal locations coincide with known quantitative trait locus (QTL) regions influencing growth traits. Here we report the genetic mapping of multiple duplicated forms of genes within this complex to previously known life-history and growth QTL regions in rainbow trout (Oncorhynchus mykiss). Specifically, duplicated copies of the 2 antizyme genes map to Om-8/9/24, while antizyme inhibitor and odc duplicates map to Om-27/31 and Om-14/25, respectively. All sets of paralogous mapping locations correspond to ancestrally duplicated synteny regions within the genome of rainbow trout (i.e., ancestral A, B, GH/I and M linkage groups). Copyright © 2009 S. Karger AG, Basel.

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