Evidence for Hox gene duplication in rainbow trout (Oncorhynchus mykiss): A tetraploid model species

TitleEvidence for Hox gene duplication in rainbow trout (Oncorhynchus mykiss): A tetraploid model species
Publication TypeJournal Article
Year of Publication2005
AuthorsMoghadam, HK, Ferguson MM, Danzmann RG
JournalJournal of Molecular Evolution
Volume61
Issue6
Pages804 - 818
KeywordsGenetic map, Hox genes, Polyploid, Rainbow trout, Salmonids, Teleost
Abstract

We examined the genomic organization of Hox genes in rainbow trout (Oncorhynchus mykiss), a tetraploid teleost derivative species, in order to test models of presumptive genomic duplications during vertebrate evolution. Thirteen putative clusters were localized in the current rainbow trout genetic map; however, analysis of the sequence data suggests the presence of at least 14 Hox clusters. Many duplicated genes appear to have been retained in the genome and share a high percentage of amino acid similarity with one another. We characterized two Hox genes located within the HoxCb cluster that may have been lost independently in other teleost species studied to date. Finally, we identified conserved syntenic blocks between salmonids and human, and provide data supporting two new linkage group homeologies (i.e., RT-3/16, RT-12/29) and three previously described homeologies (RT-2/9, RT-17/22, and RT-27/31) in rainbow trout. © Springer Science+Business Media, Inc. 2005.

URLhttp://www.scopus.com/inward/record.url?eid=2-s2.0-27744471365&partnerID=40&md5=7a9ed0ac1eb35a7debee074211b7d54f

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