Dietary fish oil replacement does not alter quinolone uptake in gilthead seabream

TitleDietary fish oil replacement does not alter quinolone uptake in gilthead seabream
Publication TypeJournal Article
Year of Publication2012
AuthorsRigos, G, Zonaras V, Cotou E, Henry M, Nikoloudaki X, Alexis M
JournalBulletin of the European Association of Fish Pathologists
Pages94 - 102

The effects of fish oil replacement on the availability of oxolinic acid (OA) and flumequine (FLU) were investigated in gilthead sea bream (Sparus aurata). Two experimental feeds were used containing 15% (FO diet) or 5% fish oil (VO diet), the later replaced by rapeseed, linseed and palm oil. Fish received through the diet a dosage of 30 or 75 mg OA/kg fish for 7 days at 26°C water temperature. FLU was administered at 30 mg/kg fish for 5 days at 26 or 13°C. Fish given FO diets showed insignificantly higher OA plasma levels compared to those receiving VO feeds. Maximum OA plasma concentrations were measured to be 0.13 and 0.08 ug/ml for the FO and VO groups, respectively at standard dosage. A small increase of OA levels in plasma was observed in FO and VO group (0.14 vs.0.13 μg/ml) when fish were administered double drug dosing. Circulatory FLU levels were also measured to be low and insignificantly different between the two groups at the low water temperature. They were higher compared to those measured at 26°C with peaked concentrations of 0.15 and 0.17 μg/ml for FO and VO groups, respectively vs. 0.085 and 0.083 μg/ ml at 13 °C. Overall, low quinolone levels were measured in circulation of gilthead sea bream fed alternative diets. Reduction of the dietary fish oil level induced insignificant effects on the uptake of OA and FLU in this species.


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