Analysis of the Sox gene family in the European sea bass (Dicentrarchus labrax)

TitleAnalysis of the Sox gene family in the European sea bass (Dicentrarchus labrax)
Publication TypeJournal Article
Year of Publication2004
AuthorsGalay-Burgos, M, Llewellyn L, Mylonas CC, Canario AVM, Zanuy S, Sweeney GE
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Pages279 - 284
KeywordsGene Duplication, Gene family, PCR, Sea bass, Sex determination, Sox genes

Sox (SRY-related genes containing a HMG box) genes encode a family of transcription factors that are involved in a variety of developmental processes including sex determination. Twenty Sox genes are present in the genomes of humans and mice, but far less is known about the Sox gene family in other vertebrate types. We have obtained clones representing the HMG boxes of twelve Sox genes from European sea bass (Dicentrarchus labrax), a fish species whose farming is complicated by a heavily skewed sex ratio, with between 70% and 99% of offspring typically being male. The cloned Sox genes are members of the SoxB, SoxC, SoxE and SoxF groups. Sequence analysis shows that some of the clones represent genes duplicated in sea bass with respect to the mammalian Sox gene family. © 2004 Elsevier Inc. All rights reserved.


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